Optimized Exon-Exon Junction Library and its Application on Rodents' Brain Transcriptome Analysis
نویسندگان
چکیده
منابع مشابه
JETTA: junction and exon toolkits for transcriptome analysis
SUMMARY High-throughput genome-wide studies of alternatively spliced mRNA transcripts have become increasingly important in clinical research. Consequently, easy-to-use software tools are required to process data from these studies, for example, using exon and junction arrays. Here, we introduce JETTA, an integrated software package for the calculation of gene expression indices as well as the ...
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Nonsense-mediated messenger RNA (mRNA) decay, or NMD, is a critical process of selective degradation of mRNAs that contain premature stop codons. NMD depends on both pre-mRNA splicing and translation, and it requires recognition of the position of stop codons relative to exon-exon junctions. A key factor in NMD is hUpf3, a mostly nuclear protein that shuttles between the nucleus and cytoplasm a...
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ژورنال
عنوان ژورنال: Brazilian Archives of Biology and Technology
سال: 2017
ISSN: 1516-8913
DOI: 10.1590/1678-4324-2016160240